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Search Results for " mineralocorticoid receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T14301 Apararenone MT-3995 Glucocorticoid Receptor
Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.
T0476 Spironolactone SC9420,Abbolactone Glucocorticoid Receptor , Androgen Receptor , Autophagy
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T9022 AZD9977 AZD 9977 Glucocorticoid Receptor
AZD9977 is a novel, selective modulator of mineralocorticoid receptor .
T4277 Osilodrostat LCI699 Glucocorticoid Receptor , Others , Hydroxylase
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
T15246 Esaxerenone XL-550,CS-3150 Glucocorticoid Receptor
Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
T17217 Vamorolone VBP15 Glucocorticoid Receptor , NF-κB
Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition an...
T0083 Eplerenone Epoxymexrenone,CGP 30083,SC-66110 Glucocorticoid Receptor
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ...
T0354 Canrenone 6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,RP-11614,SC14266 Glucocorticoid Receptor , Endogenous Metabolite
Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.
T3096 Canrenoate potassium Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone Glucocorticoid Receptor
Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.
T3033 Deoxycorticosterone acetate DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T21395 Finerenone BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 Glucocorticoid Receptor
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862...
T1666L Fludrocortisone 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,Fludrocortisone acetate,Astonin,9α-Fluorcortisol Others
Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. Fludrocortisone can be used to studies on treating low blood pressure.
T1666 Fludrocortisone acetate 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate Glucocorticoid Receptor , Autophagy
Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon...
TN3910 Ecdysone Apoptosis , ATPase , Glucocorticoid Receptor , Potassium Channel , Sodium Channel , Endogenous Metabolite , Autophagy
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell a...
T32368 KB-74935 KB 74935 Others
KB-74935 is an enzyme inhibitor and a mineralocorticoid receptor antagonist used to treat cholesterol, hypolipidemia, neurological disorders, and Alzheimer's disease.
T13881 Dicirenone SC26304 ATPase , Glucocorticoid Receptor
Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors.
T16502 PF-3882845 Others
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for ...
T17291 ZK 216348 (+)-ZK 216348 Others
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an an...
T23272 RU 28318, potassium salt Others
mineralocorticoid receptor (MR) antagonist
T68699 Oxprenoate Free Base
Oxprenoate Free Base is a mineralocorticoid receptor (MR) antagonist, inhibiting aldosterone production and secretion.

Compounds

Apararenone
T14301
Synonym: MT-3995
Target: Glucocorticoid Receptor
Spironolactone
T0476
Synonym: SC9420,Abbolactone
Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy
AZD9977
T9022
Synonym: AZD 9977
Target: Glucocorticoid Receptor
Osilodrostat
T4277
Synonym: LCI699
Target: Glucocorticoid Receptor, Others, Hydroxylase
Esaxerenone
T15246
Synonym: XL-550,CS-3150
Target: Glucocorticoid Receptor
Vamorolone
T17217
Synonym: VBP15
Target: Glucocorticoid Receptor, NF-κB
Eplerenone
T0083
Synonym: Epoxymexrenone,CGP 30083,SC-66110
Target: Glucocorticoid Receptor
Canrenone
T0354
Synonym: 6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,RP-11614,SC14266
Target: Glucocorticoid Receptor, Endogenous Metabolite
Canrenoate potassium
T3096
Synonym: Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone
Target: Glucocorticoid Receptor
Deoxycorticosterone acetate
T3033
Synonym: DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate
Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor
Finerenone
T21395
Synonym: BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862
Target: Glucocorticoid Receptor
Fludrocortisone
T1666L
Synonym: 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,Fludrocortisone acetate,Astonin,9α-Fluorcortisol
Target: Others
Fludrocortisone acetate
T1666
Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate
Target: Glucocorticoid Receptor, Autophagy
Ecdysone
TN3910
Synonym:
Target: Apoptosis, ATPase, Glucocorticoid Receptor, Potassium Channel, Sodium Channel, Endogenous Metabolite, Autophagy
KB-74935
T32368
Synonym: KB 74935
Target: Others
Dicirenone
T13881
Synonym: SC26304
Target: ATPase, Glucocorticoid Receptor
PF-3882845
T16502
Synonym:
Target: Others
ZK 216348
T17291
Synonym: (+)-ZK 216348
Target: Others
RU 28318, potassium salt
T23272
Synonym:
Target: Others
Oxprenoate Free Base
T68699
Synonym:
Target:
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TargetMol